Founded in 1902 by Townsend W. Thorndike, Henry I. Bowditch, Francis W. Palfrey, William C. Quinby, and Samuel Robinson during their fourth year at HMS. In the early period of the Aesculapian Club there existed a strong sentiment in favor of its serving a purely social purpose, and quickly the members decided that life was too short to be wasted entirely on the art of medicine and the club added a number of purely social pursuits to its endeavors, most notably the Second Year Show, which began in 1907. Since that time the Aesculapian Club has devoted itself whole-heartedly to improving life at HMS for students. 

Aesculapian Club gifts/contributions made to HMS include:

• The Second Year Show 
• Aesculapian Room in the Countway Library
• White Coats since 1994
• In Vanderbilt Hall:  
  • Steinway Piano
  • Deanery Lounge
  • Culver Lounge
• The Aesculapiad (Yearbook)
• HMS Aesculapian Club Student Symposium
• FABRIC (An annual production by HMS and HSDM first-year students during Revisit)
• Class of 2019 Graduation Ball
• Student Council Spring Formal